|The remains of Grand Duke Francesco I de' Medici|
By the time Don Antonio dusted off the cobwebs at the Casino and restarted the laboratory there in his early twenties, he had already experienced more than his share of misfortune. At the age of eleven, his life was suddenly changed forever when he lost both parents. Among many other implications, it meant relinquishing his future as grand duke of Tuscany to his uncle Ferdinando. Cardinal Ferdinando de' Medici had been visiting his brother, Grand Duke Francesco and his wife Bianca when they both became violently ill and died within days of each other in the fall of 1587. It was no secret that the brothers had running quarrels on a variety of matters from the cardinal's allowance to the way Francesco was running Tuscany. It was also no secret that Cardinal Ferdinando strongly disapproved of his older brother's wife, Bianca Cappello. She had earlier been the duke's mistress; they married in secret shortly after Grand Duchess Giovanna died in pregnancy.
As soon as Francesco and Bianca's deaths were made public, rumors began to fly that the cause was poison in their food and not pernicious malaria, as pronounced by Ferdinando's own two doctors, Cini and Da Barga. Related rumors claimed that Don Antonio was an illegitimate child, or adopted, or even the product of witchcraft, none of which hurt Ferdinando's case for succeeding his brother as grand duke. The narrative was that Ferdinando had made a ruthless power grab, assassinating his brother and sister-in-law; it was a narrative that spread and gained momentum over the years, fueled by careless researchers and Victorian era romanticism. In some nineteenth and twentieth century history books, it was reported as all but fact. The poisoning of Ferdinando and Bianca has been the subject of theatrical productions, novels, poetry, paintings and a musical composition. Admittedly, it does have all the elements of a great story: Marriage for love in the aristocracy, sex, murder, intrigue, politics and religion. Truth be told, given the Medici family’s actual history, the story is not all that far-fetched, but it turns out not to be true, at least as far as modern forensics technology can determine.
Controversy erupted in 2007 when a team from the University of Florence reported that they had unearthed what they presumed to be the long-lost (but partial) remains of Grand Duchess Bianca. Testing revealed a significant level of arsenic, leading some to give assassination another look. Others pointed out that arsenic was commonly used as an embalming preservative in this period. Meanwhile, a team at the University of Pisa confirmed that there are malaria pathogens in what are not disputed to be Francesco's remains, interred at the Chapel of Princes in Florence.
Ferdinando's two physicians, Giulio Cini and Giulio Angeli da Barga, who were on the scene in October of 1587, reported that symptoms were identical in both patients. Modern forensics pathologists agree that those symptoms are entirely consistent with pernicious malaria. Furthermore, it was recorded that a few days earlier, Francesco and Bianca had ventured into a swampy area on a walk near the estate where they met their end. In fact, Francesco had lost two younger brothers and his mother to malaria, and I can personally vouch that Tuscan mosquitoes are nasty little creatures. If not for an insect bite, Don Antonio might well have become the third grand duke. As it was, Ferdinando took the reigns of power and Antonio Neri's father was appointed to be the new grand duke's royal physician, with Cini and da Barga his assistants.